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. 2022 Mar 17;36(7-9):480–504. doi: 10.1089/ars.2021.0023

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© Sharmila Fagoonee et al., 2022; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 9. — Analysis of CCl₄-treated, non-cholestatic mice. (A) Collagen deposits (red) were analyzed by PSR staining in the livers of mice treated with CCl₄ for 4 and 6 weeks with respect to vehicle-treated mice (OIL) (n = 14). (B) Biochemical parameters analysis (n = 6). (C) Fibrosis-related gene expression analysis (n = 6). (D) miRNAs identified as enriched in circulating by RNA-seq in the BDL model were analyzed by qRT-PCR. Data show mean ± SEM of abundance of each miRNA in circulating EVs (n ≥ 4). (E) Data show mean ± SEM of abundance of each miRNA in the liver of CCl₄-treated mice by qRT-PCR (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001. OIL, corn oil. Color images are available online.

FIG. 9. — Analysis of CCl₄-treated, non-cholestatic mice. (A) Collagen deposits (red) were analyzed by PSR staining in the livers of mice treated with CCl₄ for 4 and 6 weeks with respect to vehicle-treated mice (OIL) (n = 14). (B) Biochemical parameters analysis (n = 6). (C) Fibrosis-related gene expression analysis (n = 6). (D) miRNAs identified as enriched in circulating by RNA-seq in the BDL model were analyzed by qRT-PCR. Data show mean ± SEM of abundance of each miRNA in circulating EVs (n ≥ 4). (E) Data show mean ± SEM of abundance of each miRNA in the liver of CCl₄-treated mice by qRT-PCR (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001. OIL, corn oil. Color images are available online.