FIGURE 2.

BXD32 retinas degenerate rapidly when observed by OCT. WT (A) and BXD32 (B) mice were anesthetized and had their retinas imaged by OCT. p63 BXD32 mice already demonstrate thinning of both the ONL (orange caliper) and the total retina (light blue caliper) compared to WT. This thinning increases rapidly until almost no ONL exists by p168. (C) ONL measurements were taken from tiled DAPI stained retinal sections through the ONH at distances of 500, 1,000, 1,500, and 2000 μm superiorly and inferiorly to the ONH and graphed as a spidergram. Examples of typical retinal tiled images are shown in (D).