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. 2022 Mar 21;13:839424. doi: 10.3389/fphar.2022.839424

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Copyright © 2022 Hollingsworth, Wang, White, Simpson and Jablonski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The BXD32 mouse retina shows aberrant phagocytosis of living photoreceptors by monocytes. Using TUNEL labeling (red) for apoptotic nuclei (arrowheads, >) and immunolabeling for monocytes (IBA1, green) and photoreceptors (RHO, blue) at p63 (A), p84 (B), p105 (C,D), and p126 (E,F), monocytes of either microglial or bloodborne origins can be observed phagocytosing non-apoptotic photoreceptors (arrows), a process known as phagoptosis. Nuclei stained with DAPI (white/grey). ROS/IS, rod outer segments/inner segments; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer. Scale bars = 10 μm.