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. 2022 Mar 21;13:839424. doi: 10.3389/fphar.2022.839424

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Copyright © 2022 Hollingsworth, Wang, White, Simpson and Jablonski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activation of STAT3 by JAK phosphorylation is observed in the BXD32 mouse retina. Using immunolabeling for pSTAT3 at tyrosine 705 (pSTAT3-Y705, red), total STAT3 (green) and the inhibitory protein SOCS3 (blue), the BXD32 mouse retina exhibits both increased expression of total STAT3 and the inhibitory protein SOCS3, while also having substantial STAT3-Y705 phosphorylation which increases with age from p63 (A) to p105 (B) up through p168 (C). This pSTAT3 labeling is observed in multiple cell layers of the retina including the ONL, INL and GCL. Nuclei stained with DAPI (white/grey). RPE, retinal pigment epithelium; ROS/IS, rod outer segments/inner segments; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer. Scale bars = 20 μm.