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. 2022 Mar 21;13:839424. doi: 10.3389/fphar.2022.839424

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Copyright © 2022 Hollingsworth, Wang, White, Simpson and Jablonski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BXD32 mouse retinas also exhibit STAT3 phosphorylation at serine 727, a multifunctional phosphorylation site. Using immunolabeling for pSTAT3 at serine 727 (pSTAT3-S727, red), total STAT3 (green), and SOCS3 (blue), it is observed that BXD32 retinas have excessive phosphorylation on STAT3-S727, a phosphorylation site serving multiple functions, two of which are the initiation of dephosphorylation of Y705, the inactivation step of STAT3, and upregulation of the mRNA for SOCS3. This upregulation can be observed in p63 (A), p105 (B), and p168 (C) retinas. The upregulation of both STAT3 and SOCS3 can also be observed in these sections. Nuclei stained with DAPI (white/grey). RPE, retinal pigment epithelium; ROS/IS, rod outer segments/inner segments; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer. Scale bars = 20 μm.