Values of IC50 (μM) and selectivity index (SI) for the synthesized thiazolium compounds against ovarian cancer (SKOV-3) and normal human skin fibroblast (HSF) cell lines, in comparison with a clinical drug (CDDP).
| Cell line | IC50 (μM) ± SD | ||||||
|---|---|---|---|---|---|---|---|
| 3a | 3b | 3c | 4a | 4b | 4c | CDDP | |
| SKOV-3 | 77.95 ± 1.35 | 35.73 ± 1.03 | 51.07 ± 2.33 | 21.31 ± 1.05 | 7.37 ± 1.11 | 15.22 ± 1.23 | 79.48 ± 1.18 |
| HSF | 177.52 ± 8.79 | 152.24 ± 9.15 | 191.26 ± 9.85 | 113.19 ± 7.39 | 75.42 ± 8.09 | 91.81 ± 7.35 | 58.28 ± 6.67 |
| SI | 2.28 | 4.26 | 3.76 | 5.87 | 10.23 | 6.03 | 0.73 |