TABLE 3.
Pharmacokinetics for antibiotics given intraperitonally to noninfected rats with uranyl nitrate-induced renal impairment
| β-Lactam agent | No. of animals | Dose (mg/kg) | Median (range) antibiotic level (μg/ml) in plasma
|
Protein binding (%)a | Half-life (h)a | Area under curve (μg · h/ml)a | |
|---|---|---|---|---|---|---|---|
| Peak (30 min after dosing) | Trough (8 h after dosing) | ||||||
| Imipenem | 5 | 30 | 83 (66–104) | <0.5 (<0.5–1) | 37 (30–53) | 1.0 (0.7–1.3) | 112 (95–145) |
| Meropenem | 6 | 30 | 76 (61–96) | <0.5 (<0.5–<0.5) | 48 (37–57) | 0.9 (0.6–1.4) | 102 (94–136) |
| Cefepime | 6 | 60 | 160 (125–220) | 12 (6–28) | 17 (12–24) | 2.0 (1.4–2.8) | 422 (188–615) |
| Ceftazidime | 4 | 60 | 197 (139–214) | 15 (5–24) | 20 (9–22) | 2.2 (1.9–2.6) | 346 (266–382) |
a
Median, with range in parentheses.