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. 2022 Mar 21;13:854025. doi: 10.3389/fphar.2022.854025

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Copyright © 2022 Yan, Lv, Tong, Yan, Chen, Zhou, Yuan, Guo and Shan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of ADSCs on MIA-induced rat OA model. (A) Safranin O/Fast green (SO) staining and alcian blue hematoxylin (ABH) staining with black arrows (chondrocyte loss, collagen disruption) and yellow arrows (chondrocyte loss, matrix disorganization). The tissue was harvested at the fourth week after OA induction, which was the fifth week of the total experiment (5 W). The white dash line indicates the border between cartilage and subchondral bone. Scale bars = 50 μm. (B) Measurement of MWT and TWL of rats. N = 8. (C) Mankin’s scores for histopathological observation. Values were presented as mean ± SD. N = 24. ##p < 0.01 versus NC group; *p < 0.05 versus model group.