TABLE 4.
Multivariable logistic regression analysis of variables associated with poor neurological outcome and cognitive impairment at 6 months, and Cox proportional-hazards regression analysis of long-term cognitive impairment during follow-up of patients with subarachnoid hemorrhage expressing haptoglobin 2-1.
| 6-month poor outcome | 6-month cognitive impairment | Long-term cognitive impairment | ||||
| (n = 126) |
(n = 113)* |
(n = 102)** |
||||
| Variables | OR (95% CI) | p-value | OR (95% CI) | p-value | HR (95% CI) | p-value |
| Clinical variables | ||||||
| Female | 1.053 (0.309−3.588) | 0.935 | 1.156 (0.201−6.633) | 0.871 | 1.059 (0.152−7.369) | 0.954 |
| Age, years | 1.021 (0.981−1.062) | 0.311 | 1.018 (0.957−1.082) | 0.579 | 1.017 (0.961−1.075) | 0.558 |
| Hypertension | 1.508 (0.529−4.299) | 0.442 | 0.451 (0.119−1.716) | 0.243 | 0.879 (0.193−3.998) | 0.867 |
| Diabetes mellitus | 0.923 (0.210−4.061) | 0.915 | 0.512 (0.045−5.858) | 0.591 | 0.461 (0.050−4.288) | 0.496 |
| Hyperlipidemia | 0.644 (0.170−2.440) | 0.517 | 0.270 (0.022−3.384) | 0.310 | 0.377 (0.046−3.065) | 0.362 |
| Smoking | 0.283 (0.033−2.429) | 0.250 | 0.361 (0.037−3.561) | 0.383 | 0.310 (0.026−3.687) | 0.354 |
| Radiological variables | ||||||
| Hunt and Hess grade IV and V | 4.500 (1.690−11.983) | 0.003 | 1.722 (0.332−8.938) | 0.517 | 1.521 (0.315−7.344) | 0.601 |
| Fisher grade III and IV | 1.736 (0.540−5.583) | 0.355 | 11.702 (1.444−94.816) | 0.021 | 8.140 (1.021−64.880) | 0.048 |
| Anterior circulation aneurysm | 0.548 (0.129−2.323) | 0.415 | 0.986 (0.129−7.513) | 0.989 | 0.424 (0.045−3.979) | 0.452 |
| Hydrocephalus | 1.660 (0.340−8.098) | 0.531 | 3.457 (0.519−23.012) | 0.200 | 3.177 (0.670−15.075) | 0.146 |
| Severe vasospasm | 0.643 (0.201−2.058) | 0.457 | 1.458 (0.325−6.550) | 0.623 | 2.033 (0.526−7.847) | 0.303 |
| Treatment methods | ||||||
| Coil embolization | 0.621 (0.184−2.102) | 0.444 | 1.227 (0.207−7.280) | 0.822 | 1.360 (0.215−8.614) | 0.744 |
| Haptoglobin | ||||||
| Relative α1 / albumin intensity | 0.010 (0.000−0.522) | 0.022 | 2.589 (0.116−57.989) | 0.549 | 3.813 (0.312−46.644) | 0.295 |
*, ** Six month-cognitive impairment was analyzed in 113 patients with Hp2-1, and long-term cognitive impairment was analyzed in 102 patients with Hp2-1. OR, odds ratio; CI, confidence interval; HR, hazards ratio.