TABLE 2.
MICs of β-lactams for P. aeruginosa COL-1, E. coli DH10B harboring recombinant plasmid pNOR-2001, and E. coli reference strain DH10B
| β-Lactam(s)a | MIC (μg/ml)
|
||
|---|---|---|---|
| P. aeruginosa COL-1 | E. coli DH10B (pNOR-2001)b | E. coli DH10B | |
| Amoxicillin | >512 | >512 | 4 |
| Amoxicillin + CLA | >512 | 512 | 4 |
| Ticarcillin | >512 | >512 | 4 |
| Ticarcillin + CLA | >512 | 512 | 4 |
| Piperacillin | 64 | 4 | 1 |
| Piperacillin + TZB | 16 | 4 | 1 |
| Cephalothin | >512 | 256 | 2 |
| Cefoxitin | >512 | 128 | 1 |
| Ceftazidime | 256 | 16 | 0.5 |
| Cefotaxime | >512 | 8 | 0.06 |
| Cefepime | 64 | 0.06 | 0.03 |
| Aztreonam | 0.25 | 0.12 | 0.12 |
| Meropenem | 128 | 0.25 | 0.06 |
| Imipenem | 128 | 1 | 0.12 |
a
CLA, clavulanic acid at a fixed concentration of 2 μg/ml; TZB, tazobactam at a fixed concentration of 4 μg/ml.
b
E. coli DH10B(pNOR-2001) expressed the carbapenem-hydrolyzing β-lactamase VIM-2.