Table 2.
Interactions in both dorsolateral prefrontal cortex (DLPFC) and amygdala from expanding schizophrenia-associated networks.
| Set A genes | Set B genes remaining in top factors | Factor number (DLPFC) | Factor number (amygdala) | Pathway |
|---|---|---|---|---|
| CACNA1C | PCBD1 | 1 | 1 | |
| CASP3 | DBNL | 1 | 1 | |
| GNAS | FSCN1 | 1 | 4 | |
| GNAS | XPO1 | 3 | 5 | |
| HTR3A | FITM2 | 1 | 1 | |
| HTR3A | HIST1H1C | 9 | 6 | |
| MAPK3 | TEK | 3 | 2 | Serotonergic synapse pathway |
| MAPK3 | DUSP5 | 19 | 6 | |
| PLA2G4A | JAK1 | 3 | 1 | |
| PRKCA | FSCN1 | 1 | 4 | |
| PRKCA | HIST1H1C | 9 | 6 | |
| PRKCA | AKAP12 | 3 | 7 | |
| SLC18A1 | EMC7 | 3 | 2 | |
| CHRNA3 | TMEM219 | 1 | 1 | |
| GABBR1 | DDIT3 | 1 | 6 | |
| GRIN1 | CAMK2G | 1 | 4 | |
| GRIN2A | PTK2B | 2 | 2 | |
| GRIN2B | CAMK2G | 1 | 4 | Neuroactive ligand–receptor interaction |
| LPAR1 | FITM2 | 1 | 1 | |
| NR3C1 | SMARCC2 | 2 | 2 | |
| PTGER3 | RETSAT | 1 | 3 | |
| VIPR2 | FITM2 | 1 | 1 | |
| CACNA1C | PCBD1 | 1 | 1 | |
| GNAS | FSCN1 | 1 | 4 | |
| GNAS | XPO1 | 3 | 5 | |
| GRIN1 | CAMK2G | 1 | 4 | |
| GRIN2A | PTK2B | 2 | 2 | |
| GRIN2B | CAMK2G | 1 | 4 | |
| MAPK3 | TEK | 3 | 2 | Glutamatergic synapse pathway |
| MAPK3 | DUSP5 | 19 | 6 | |
| PLA2G4A | JAK1 | 3 | 1 | |
| PRKCA | FSCN1 | 1 | 4 | |
| PRKCA | HIST1H1C | 9 | 6 | |
| PRKCA | AKAP12 | 3 | 7 | |
| SHANK3 | CRKL | 2 | 1 | |
| AKT1 | SMARCC2 | 2 | 2 | |
| AKT1 | FAM110C | 3 | 2 | |
| AKT1 | TEK | 3 | 2 | |
| AKT1 | DCTN1 | 1 | 4 | |
| AKT1 | TCOF1 | 2 | 4 | |
| ARRB2 | SF3B1 | 3 | 2 | |
| ARRB2 | SMARCC2 | 2 | 2 | |
| ARRB2 | RPLP0 | 9 | 2 | |
| ARRB2 | RPL22 | 3 | 3 | |
| ARRB2 | TCOF1 | 2 | 4 | |
| ARRB2 | XPO1 | 3 | 5 | |
| ARRB2 | HIST1H1C | 9 | 6 | |
| ARRB2 | SF3B2 | 1 | 10 | |
| CACNA1C | PCBD1 | 1 | 1 | |
| CALM1 | SF3B1 | 3 | 2 | |
| CALM1 | RPL22 | 3 | 3 | |
| CALM1 | CAMK2G | 1 | 4 | |
| CAMK2A | DBNL | 1 | 1 | Dopaminergic synapse pathway |
| CAMK2A | ARL3 | 3 | 4 | |
| CAMK2A | CAMK2G | 1 | 4 | |
| CAMK2A | DCTN1 | 1 | 4 | |
| GNAS | FSCN1 | 1 | 4 | |
| GNAS | XPO1 | 3 | 5 | |
| GRIN2A | PTK2B | 2 | 2 | |
| GRIN2B | CAMK2G | 1 | 4 | |
| GSK3A | RBM8A | 1 | 3 | |
| GSK3B | C14orf1 | 3 | 1 | |
| GSK3B | SF3B1 | 3 | 2 | |
| GSK3B | TLE1 | 2 | 4 | |
| GSK3B | RNF220 | 1 | 4 | |
| GSK3B | XPO1 | 3 | 5 | |
| PPP2R2B | PPP4C | 1 | 1 | |
| PRKCA | FSCN1 | 1 | 4 | |
| PRKCA | HIST1H1C | 9 | 6 | |
| PRKCA | AKAP12 | 3 | 7 | |
| SLC18A1 | EMC7 | 3 | 2 | |
| AKT1 | SMARCC2 | 2 | 2 | |
| AKT1 | FAM110C | 3 | 2 | |
| AKT1 | TEK | 3 | 2 | |
| AKT1 | DCTN1 | 1 | 4 | |
| AKT1 | TCOF1 | 2 | 4 | |
| CACNA1C | PCBD1 | 1 | 1 | |
| CALM1 | SF3B1 | 3 | 2 | |
| CALM1 | RPL22 | 3 | 3 | |
| CALM1 | CAMK2G | 1 | 4 | |
| CAMK2A | DBNL | 1 | 1 | |
| CAMK2A | ARL3 | 3 | 4 | |
| CAMK2A | CAMK2G | 1 | 4 | |
| CAMK2A | DCTN1 | 1 | 4 | |
| GABBR1 | DDIT3 | 1 | 6 | |
| GNAS | FSCN1 | 1 | 4 | |
| GNAS | XPO1 | 3 | 5 | cAMP signaling pathway |
| GRIN1 | CAMK2G | 1 | 4 | |
| GRIN2A | PTK2B | 2 | 2 | |
| GRIN2B | CAMK2G | 1 | 4 | |
| MAPK3 | TEK | 3 | 2 | |
| MAPK3 | DUSP5 | 19 | 6 | |
| PDE4B | XPO1 | 3 | 5 | |
| PDE4D | AKAP12 | 3 | 7 | |
| PTGER3 | RETSAT | 1 | 3 | |
| RELA | PPP4C | 1 | 1 | |
| RELA | SETD6 | 3 | 1 | |
| RELA | MKRN2 | 3 | 1 | |
| RELA | MACROD1 | 1 | 1 | |
| RELA | AATF | 3 | 2 | |
| RELA | TLE1 | 2 | 4 | |
| RELA | XPO1 | 3 | 5 | |
| VIPR2 | FITM2 | 1 | 1 |