Table 3.
Hub genes from known SCZ-associated genes (gene set A) and from gene set B with supportive evidence from at least two pathways.
| GeneID | Pathway | GWAS | Linkage association studies | CNV | Differential methylations | Differential expression | Exome mutations | Brain expression |
|---|---|---|---|---|---|---|---|---|
| Hub genes from gene set A | ||||||||
| CACNA1C | mGluR, dopamine synapse, cAMP, serotonergic synapse | 1 | 0 | 0 | 1 | 0 | 1 | High |
| GNAS | mGluR, dopamine synapse, cAMP, serotonergic synapse | 0 | 0 | 0 | 1 | 0 | 1 | High |
| GRIA1 | mGluR, dopamine synapse, cAMP, neuroactive ligand–receptor interaction | 0 | 1 | 0 | 0 | 0 | 0 | High |
| GRIA3 | mGluR, dopamine synapse, cAMP, neuroactive ligand–receptor interaction | 0 | 0 | 0 | 0 | 0 | 1 | High |
| DRD2 | Dopamine synapse, neuroactive ligand–receptor interaction, cAMP | 1 | 1 | 0 | 0 | 0 | 0 | Low |
| GNAO1 | mGluR, dopamine synapse, serotonergic synapse | 0 | 0 | 0 | 0 | 0 | 1 | High |
| MAPK3 | mGluR, cAMP, serotonergic synapse | 0 | 0 | 1 | 0 | 0 | 0 | High |
| PLCB1 | mGluR, dopamine synapse, serotonergic synapse | 0 | 0 | 0 | 1 | 0 | 0 | High |
| PRKCA | mGluR, dopamine synapse, serotonergic synapse | 0 | 0 | 0 | 1 | 0 | 0 | High |
| AKT1 | Dopamine synapse, cAMP | 0 | 1 | 0 | 0 | 0 | 1 | High |
| CACNA1B | Dopamine synapse, serotonergic synapse | 0 | 0 | 0 | 0 | 0 | 1 | High |
| CALM1 | Dopamine synapse, cAMP | 0 | 0 | 0 | 1 | 0 | 0 | High |
| CAMK2A | Dopamine synapse, cAMP | 0 | 0 | 0 | 0 | 0 | 1 | High |
| CAMK2B | Dopamine synapse, cAMP | 0 | 0 | 0 | 0 | 0 | 1 | High |
| DRD3 | Dopamine synapse, neuroactive ligand–receptor interaction | 0 | 1 | 0 | 0 | 0 | 1 | Low |
| GRIK5 | mGluR, neuroactive ligand–receptor interaction | 0 | 0 | 0 | 0 | 0 | 1 | High |
| MAPK8 | Dopamine synapse, cAMP | 0 | 0 | 0 | 0 | 0 | 1 | High |
| PLA2G4A | mGluR, serotonergic synapse | 0 | 1 | 0 | 0 | 0 | 0 | Low |
| PPP3CC | mGluR, dopamine synapse | 0 | 1 | 0 | 0 | 0 | 0 | High |
| PTGER3 | Neuroactive ligand–receptor interaction, cAMP | 0 | 0 | 0 | 0 | 0 | 1 | Low |
| SLC18A1 | Dopamine synapse, serotonergic synapse | 0 | 1 | 0 | 0 | 0 | 0 | Low |
| VIPR2 | Neuroactive ligand–receptor interaction, cAMP | 0 | 0 | 1 | 0 | 0 | 0 | Low |
| Hub genes from gene set B | ||||||||
| CAMK2G | mGluR, dopamine synapse, cAMP, neuroactive ligand–receptor interaction | 0 | 0 | 0 | 1 | 1 | 0 | High |
| MYC | mGluR, dopamine synapse, cAMP, serotonergic synapse | 0 | 0 | 0 | 1 | 0 | 0 | High |
| SDCBP | mGluR, dopamine synapse, cAMP, neuroactive ligand–receptor interaction | 0 | 0 | 0 | 0 | 0 | 1 | High |
| ARNT | Dopamine synapse, cAMP, serotonergic synapse | 0 | 1 | 0 | 0 | 0 | 0 | High |
| EPB41L1 | Dopamine synapse, neuroactive ligand–receptor interaction, cAMP | 0 | 0 | 0 | 0 | 0 | 1 | High |
| ERBB2 | Dopamine synapse, neuroactive ligand–receptor interaction, cAMP | 0 | 0 | 0 | 0 | 0 | 1 | High |
| FSCN1 | mGluR, dopamine synapse, serotonergic synapse | 0 | 0 | 0 | 1 | 1 | 1 | High |
| SLC9A3R1 | mGluR, dopamine synapse, serotonergic synapse | 0 | 0 | 0 | 0 | 0 | 1 | High |
| AURKA | Dopamine synapse, cAMP | 0 | 0 | 0 | 0 | 0 | 1 | Low |
| CDK4 | Dopamine synapse, cAMP | 0 | 0 | 0 | 1 | 0 | 1 | High |
| CLIC6 | Dopamine synapse, neuroactive ligand–receptor interaction | 0 | 0 | 0 | 0 | 0 | 1 | Low |
| CMTM4 | Neuroactive ligand–receptor interaction, cAMP | 0 | 0 | 0 | 1 | 0 | 0 | High |
| DCTN1 | Dopamine synapse, cAMP | 0 | 0 | 0 | 0 | 0 | 1 | High |
| DERL1 | cAMP, serotonergic synapse | 0 | 0 | 0 | 1 | 1 | 0 | High |
| DGUOK | Dopamine synapse, cAMP | 0 | 0 | 0 | 0 | 0 | 1 | High |
| EIF2AK3 | Dopamine synapse, cAMP | 0 | 0 | 0 | 1 | 0 | 0 | High |
| FUS | Dopamine synapse, cAMP | 0 | 0 | 0 | 1 | 0 | 0 | High |
| GNB2 | Dopamine synapse, cAMP | 0 | 0 | 0 | 1 | 0 | 1 | High |
| GRID2 | mGluR, neuroactive ligand–receptor interaction | 0 | 0 | 0 | 0 | 0 | 1 | Low |
| HIST1H1C | Dopamine synapse, serotonergic synapse | 0 | 0 | 0 | 1 | 0 | 0 | High |
| ILK | Dopamine synapse, cAMP | 0 | 0 | 0 | 0 | 0 | 1 | High |
| ITPR1 | Dopamine synapse, cAMP | 0 | 0 | 0 | 1 | 0 | 1 | High |
| MAP2K1 | Dopamine synapse, cAMP | 0 | 0 | 0 | 0 | 0 | 1 | High |
| PPP1CB | Dopamine synapse, cAMP | 0 | 0 | 0 | 0 | 0 | 1 | High |
| RAF1 | Dopamine synapse, cAMP | 0 | 0 | 0 | 1 | 0 | 0 | High |
| SLC39A1 | Neuroactive ligand–receptor interaction, cAMP | 0 | 0 | 0 | 1 | 0 | 0 | High |
| SNCG | cAMP, serotonergic synapse | 0 | 0 | 0 | 0 | 0 | 1 | High |
| UBR5 | Dopamine synapse, cAMP | 0 | 0 | 0 | 1 | 0 | 1 | High |
| XPO1 | Dopamine synapse, cAMP | 0 | 0 | 0 | 1 | 1 | 1 | High |
| YWHAQ | Dopamine synapse, cAMP | 0 | 0 | 0 | 0 | 0 | 1 | High |