Table 2.
Nomenclature and details of knockout mouse genotypes, related to Figures 4 and 5. Abbreviations are as follows, +/+: homozygous wild type allele; f/f: homozygous floxed allele.
| Nomenclature | Group (Esr1 phenotype) | Esr1 phenotype | p38α phenotype | Genotype | ||
|---|---|---|---|---|---|---|
| p38α | Esr1 | LysM-Cre | ||||
| Esr1-WT | Single Esr1-CKO | WT | WT | +/+ | f/f | − |
| Esr1-CKO | CKO | WT | +/+ | f/f | + | |
| p38αWT | Single p38α-CKO | WT | WT | f/f | +/+ | − |
| p38αCKO (CKO) | WT | CKO | f/f | +/+ | + | |
| p38α/Esr1-WT | Double p38α/Esr1-CKO | WT | WT | f/f | f/f | − |
| p38α/Esr1-CKO (DKO) | CKO | CKO | f/f | f/f | + | |