TABLE 2.

The top 8 genes with genetic variants significantly enriched in ADEH+compared to ADEH−and NA (p < 0.001) revealed by the SKAT-O gene-based tests

		ADEH+ vs ADEH−				ADEH+ vs NA				ADEH− vs NA
		All missense/damaging		Rare missense/damaging		All missense/damaging		Rare missense/damaging		All missense/damaging		Rare missense/damaging
Gene	Chr	# SNVs	p-value	# SNVs	p-value	# SNVs	p-value	# SNVs	p-value	# SNVs	p-value	# SNVs	p-value
RBBP8NL	20	4	0.0014	3	0.0014	3	0.0001	2	0.0001	5	0.3000	4	0.3000
TRIM15	6	2	0.0003	2	0.0003	3	0.108	3	0.108	3	0.0435	3	0.0435
CLEC7A	12	3	0.158	2	0.537	2	0.0003	1	0.032	3	0.0305	2	0.1380
SIDT2	11	4	0.0006	4	0.0006	3	0.0003	3	0.0003	5	0.7040	5	0.7040
FRMD3	9	2	0.0034	2	0.0034	1	0.0005	1	0.0005	2	0.2400	2	0.2400
TPSG1	16	3	0.129	2	0.101	3	0.0025	2	0.0007	3	0.0122	2	0.0044
GSTZ1	14	3	0.0684	1	0.453	2	0.0007	NA	NA	3	0.1790	1	0.7410
SP110	2	3	0.0009	3	0.0009	4	0.0043	4	0.0043	2	0.7020	2	0.7020