Table 2.
Incidence of all LP-Related AEs at baseline based on LP procedure characteristics.
| Variable | All Subjects | PD Subjects | Healthy Controls | SWEDD Subjects | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
||||||||||||
| AE | No AE | p-value | AE | No AE | p-value | AE | No AE | p-value | AE | No AE | p-value | |
| Age | 0.1073 | 0.5752 | 0.1777 | 0.6316 | ||||||||
| < 56 years | 52 (27.23%) | 139 (72.77%) | 27 (23.68%) | 87 (76.32%) | 18 (32.73%) | 37 (67.27%) | 7 (31.82%) | 15 (68.18%) | ||||
| 56–65 years | 56 (22.67%) | 191 (77.33%) | 29 (19.08%) | 123 (80.92%) | 21 (27.63%) | 55 (72.37%) | 6 (31.58%) | 13 (68.42%) | ||||
| > 65 years | 45 (18.67%) | 196 (81.33%) | 29 (18.71%) | 126 (81.29%) | 12 (18.46%) | 53 (81.54%) | 4 (19.05%) | 17 (80.95%) | ||||
| Gender | 0.0004 | 0.1603 | 0.0038 | 0.0180 | ||||||||
| Male | 80 (18.18%) | 360 (81.82%) | 50 (18.12%) | 226 (81.88%) | 24 (19.05%) | 102 (80.95%) | 6 (15.79%) | 32 (84.21%) | ||||
| Female | 73 (30.54%) | 166 (69.46%) | 35 (24.14%) | 110 (75.86%) | 27 (38.57%) | 43 (61.43%) | 11 (45.83%) | 13 (54.17%) | ||||
| Type of Needle | 0.0039 | 0.0060 | 0.0782 | 0.3473 | ||||||||
| 20g Quincke | 19 (38.78%) | 30 (61.22%) | 14 (42.42%) | 19 (57.58%) | 3 (27.27%) | 8 (72.73%) | 2 (40.00%) | 3 (60.00%) | ||||
| 22g Quincke | 20 (30.30%) | 46 (69.70%) | 12 (27.27%) | 32 (72.73%) | 6 (42.86%) | 8 (57.14%) | 2 (25.00%) | 6 (75.00%) | ||||
| 25g Quincke | 1 (7.69%) | 12 (92.31%) | 0 (0.00%) | 8 (100.0%) | 1 (50.00%) | 1 (50.00%) | 0 (0.00%) | 3 (100.0%) | ||||
| 22g Sprotte | 12 (18.75%) | 52 (81.25%) | 4 (10.26%) | 35 (89.74%) | 6 (28.57%) | 15 (71.43%) | 2 (50.00%) | 2 (50.00%) | ||||
| 24g Sprotte | 92 (19.53%) | 379 (80.47%) | 51 (17.71%) | 237 (82.29%) | 32 (22.22%) | 112 (77.78%) | 9 (23.08%) | 30 (76.92%) | ||||
| 18g | 4 (50.00%) | 4 (50.00%) | 1 (20.00%) | 4 (80.00%) | 2 (100.0%) | 0 (0.00%) | 1 (100.0%) | 0 (0.00%) | ||||
| Unknown/Missing | 5 (62.50%) | 3 (37.50%) | 3 (75.00%) | 1 (25.00%) | 1 (50.00%) | 1 (50.00%) | 1 (50.00%) | 1 (50.00%) | ||||
| Method of Collection | 0.0857 | 0.3769 | 0.1713 | 0.5676 | ||||||||
| Gravity | 66 (25.58%) | 192 (74.42%) | 36 (22.09%) | 127 (77.91%) | 22 (31.88%) | 47 (68.12%) | 8 (30.77%) | 18 (69.23%) | ||||
| Syringe Suction | 82 (19.85%) | 331 (80.15%) | 46 (18.11%) | 208 (81.89%) | 28 (22.40%) | 97 (77.60%) | 8 (23.53%) | 26 (76.47%) | ||||
| Unknown/Missing | 5 (62.50%) | 3 (37.50%) | 3 (75.00%) | 1 (25.00%) | 1 (50.00%) | 1 (50.00%) | 1 (50.00%) | 1 (50.00%) | ||||
| Lumbar Puncture Site | 0.2801 | 0.3671 | 0.3285 | 0.7516 | ||||||||
| L2-L3 Interspace | 7 (20.59%) | 27 (79.41%) | 4 (17.39%) | 19 (82.61%) | 1 (14.29%) | 6 (85.71%) | 2 (50.00%) | 2 (50.00%) | ||||
| L3-L4 Interspace | 93 (20.81%) | 354 (79.19%) | 47 (17.87%) | 216 (82.13%) | 34 (23.94%) | 108 (76.06%) | 12 (28.57%) | 30 (71.43%) | ||||
| L4-L5 Interspace | 41 (26.97%) | 111 (73.03%) | 25 (24.27%) | 78 (75.73%) | 14 (35.00%) | 26 (65.00%) | 2 (22.22%) | 7 (77.78%) | ||||
| Unknown/Missing | 12 (26.09%) | 34 (73.91%) | 9 (28.13%) | 23 (71.88%) | 2 (28.57%) | 5 (71.43%) | 1 (14.29%) | 6 (85.71%) | ||||
| Subject position during LP | 0.0737 | 0.5083 | 0.1688 | 0.3495 | ||||||||
| Sitting, leaned over | 98 (23.56%) | 318 (76.44%) | 50 (19.84%) | 202 (80.16%) | 37 (29.60%) | 88 (70.40%) | 11 (28.21%) | 28 (71.79%) | ||||
| Lying, curled up on side | 41 (17.52%) | 193 (82.48%) | 25 (16.67%) | 125 (83.33%) | 13 (20.00%) | 52 (80.00%) | 3 (15.79%) | 16 (84.21%) | ||||
| Unknown/Missing | 14 (48.28%) | 15 (51.72%) | 10 (52.63%) | 9 (47.37%) | 1 (16.67%) | 5 (83.33%) | 3 (75.00%) | 1 (25.00%) | ||||
| CSF Hemoglobin | 0.4815 | 0.8795 | 0.2845 | 0.4681 | ||||||||
| < 200 ng/ml | 115 (21.70%) | 415 (78.30%) | 66 (20.12%) | 262 (79.88%) | 37 (24.03%) | 117 (75.97%) | 12 (25.00%) | 36 (75.00%) | ||||
| 200 ng/ml or above | 32 (24.62%) | 98 (75.38%) | 16 (19.05%) | 68 (80.95%) | 12 (34.29%) | 23 (65.71%) | 4 (36.36%) | 7 (63.64%) | ||||
| Missing | 6 (31.58%) | 13 (68.42%) | 3 (33.33%) | 6 (66.67%) | 2 (28.57%) | 5 (71.43%) | 1 (33.33%) | 2 (66.67%) | ||||
Note: p-values come from Fisher’s Exact Tests.