TABLE 2.
GO and KEGG analysis of DEGs in the MDN1 mutant and wild-type groups.
| Type | Id | Description | Count | p.adjust |
|---|---|---|---|---|
| MF | GO:0015267 | channel activity | 61 | 8.08E-12 |
| MF | GO:0022803 | passive transmembrane transporter activity | 61 | 8.08E-12 |
| MF | GO:0022838 | substrate-specific channel activity | 58 | 1.24E-11 |
| CC | GO:0098793 | presynapse | 57 | 7.49E-09 |
| MF | GO:0005216 | ion channel activity | 54 | 3.27E-10 |
| BP | GO:0042391 | regulation of membrane potential | 53 | 1.51E-07 |
| BP | GO:0048871 | multicellular organismal homeostasis | 52 | 5.96E-06 |
| CC | GO:0097060 | synaptic membrane | 50 | 5.00E-08 |
| MF | GO:0046873 | metal ion transmembrane transporter activity | 50 | 8.87E-08 |
| CC | GO:0062023 | collagen-containing extracellular matrix | 49 | 2.05E-08 |
| CC | GO:0043025 | neuronal cell body | 49 | 8.12E-06 |
| MF | GO:0022836 | gated channel activity | 49 | 1.25E-10 |
| BP | GO:0050804 | modulation of chemical synaptic transmission | 48 | 6.29E-06 |
| BP | GO:0099177 | regulation of trans-synaptic signaling | 48 | 6.29E-06 |
| MF | GO:0022839 | ion gated channel activity | 47 | 4.30E-10 |
| BP | GO:0072503 | cellular divalent inorganic cation homeostasis | 46 | 3.49E-04 |
| BP | GO:0023061 | signal release | 45 | 1.94E-04 |
| MF | GO:0005261 | cation channel activity | 45 | 9.86E-10 |
| MF | GO:0048018 | receptor ligand activity | 45 | 6.94E-05 |
| BP | GO:0006874 | cellular calcium ion homeostasis | 44 | 3.12E-04 |
| KEGG | hsa04080 | Neuroactive ligand-receptor interaction | 57 | 2.88E-15 |
| KEGG | hsa04024 | cAMP signaling pathway | 25 | 6.80E-04 |
| KEGG | hsa04020 | Calcium signaling pathway | 20 | 1.16E-02 |
| KEGG | hsa05204 | Chemical carcinogenesis | 17 | 2.41E-05 |
| KEGG | hsa04742 | Taste transduction | 17 | 3.31E-05 |
| KEGG | hsa04724 | Glutamatergic synapse | 16 | 1.28E-03 |
| KEGG | hsa04530 | Tight junction | 16 | 4.50E-02 |
| KEGG | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 15 | 1.18E-04 |
| KEGG | hsa04713 | Circadian entrainment | 15 | 9.93E-04 |
| KEGG | hsa04726 | Serotonergic synapse | 15 | 3.82E-03 |
| KEGG | hsa00140 | Steroid hormone biosynthesis | 14 | 3.98E-05 |
| KEGG | hsa00982 | Drug metabolism - cytochrome P450 | 14 | 1.84E-04 |
| KEGG | hsa04512 | ECM-receptor interaction | 14 | 1.13E-03 |
| KEGG | hsa04974 | Protein digestion and absorption | 14 | 3.82E-03 |
| KEGG | hsa05414 | Dilated cardiomyopathy | 13 | 6.16E-03 |
| KEGG | hsa05031 | Amphetamine addiction | 12 | 1.28E-03 |
| KEGG | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 12 | 3.28E-03 |
| KEGG | hsa04976 | Bile secretion | 12 | 9.82E-03 |
| KEGG | hsa04972 | Pancreatic secretion | 12 | 2.60E-02 |
| KEGG | hsa04913 | Ovarian steroidogenesis | 11 | 5.44E-04 |