TABLE 1.
Estimates of values for pharmacokinetic parameters in plasma and their coefficients of variation after an intravenous bolus injection of AmB
| Pharmacokinetic parameter | Formulation (dose)
|
|||||
|---|---|---|---|---|---|---|
| Fungizone (1 mg/kg) | AmB-Nsp [125] (3 mg/kg) | AmB-Nsp [12.5] (3 mg/kg) | AmB-MM [125] (1 mg/kg) | AmB-MM [125] (3 mg/kg) | AmB-MM [12.5] (3 mg/kg) | |
| t1/2α (h) | 0.125 (40)a | 0.95 (21) | 0.65 (28) | 0.18 (32) | 0.10 (24) | 0.09 (26) |
| t1/2β (h) | 19.6 (5) | 23.5 (8) | 18.2 (10) | 23.1 (21) | 23.1 (12) | 21.8 (14) |
| AUC (μg · h/ml) | 37.4 (4) | 100 (3) | 141 (8) | 47.4 (14) | 102 (10) | 96.8 (8) |
| CL (ml/h/kg) | 27 (4) | 30 (3) | 21 (8) | 21 (14) | 29 (10) | 30 (8) |
| V (ml/kg) | 253.6 (24) | 253.6 (5) | 108.4 (17) | 103 (24) | 121 (63) | 121.2 (16) |
| VSS (ml/kg) | 744 (6) | 892 (6) | 472 (11) | 672 (13) | 949 (13) | 812 (13) |
| MRT (h) | 27.9 (5) | 27.2 (6) | 23.4 (11) | 31.9 (21) | 32.4 (14) | 26.9 (14) |
a
Values in parentheses are coefficients of variation (in percent).