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Renal toxicity-related measurements obtained from creatinine levels in plasma
| Parameter | Formulation (dose)
|
|||||
|---|---|---|---|---|---|---|
| Fungizone (1 mg/kg) | AmB-Nsp [125] (3 mg/kg) | AmB-Nsp [12.5] (3 mg/kg) | AmB-MM [125] (1 mg/kg) | AmB-MM [125] (3 mg/kg) | AmB-MM [12.5] (3 mg/kg) | |
| AUCc (mg · h/100 ml) | 134 | 26.3 | 47 | 118 | 48 | 178 |
| Ccmax (mg/100 ml) | 5.0 ± 2.6a | 1.8 ± 0.4 | 1.7 ± 0.6 | 2.1 ± 0.7 | 1.9 ± 0.4 | 7.7 ± 2.6 |
| Tcmax (h) | 0.25 | 0.5 | 0.25 | 0.167 | 0.5 | 0.25 |
Mean ± standard deviation.
