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[Preprint]. 2022 Mar 28:2022.03.25.485875. [Version 1] doi: 10.1101/2022.03.25.485875

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Figure 3. — Mosaic-8b immunization protected against SARS-2 and SARS-1 challenges in K18-hACE2 mice, whereas homotypic SARS-2 immunization protected only against SARS-2. Mice were immunized and boosted with the indicated mi3 nanoparticles represented by different colors. (A) Weight changes after SARS-2 Beta or SARS-1 challenge. Mean weight in each vaccinated cohort indicated with a thick colored line. Weights of individual mice are indicated by colored dashed lines. (B) Survival after SARS-2 Beta or SARS-1 challenge. (C) Left: SARS-2 Beta infectious titers after challenge in lung tissue and oropharyngeal swabs. Right: Genomic and subgenomic SARS-2 Beta RNA copes determined by RT-PCR. (D) Left: SARS-1 infectious titers after challenge in lung tissue and oropharyngeal swabs. Right: Genomic and subgenomic SARS-1 RNA copies determined by RT-PCR. Significant differences between cohorts linked by horizontal lines are indicated by asterisks: p<0.05 = *, p<0.01 = **, p<0.001 = ***, p<0.0001 = ****.