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[Preprint]. 2022 Mar 28:2022.03.25.485875. [Version 1] doi: 10.1101/2022.03.25.485875

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Figure 4. — Mosaic-8b RBD-mi3 immunization induced binding and neutralizing antibodies in NHPs. Mismatched viruses are indicated by pink rectangular boxes. (A) Left: Immunization schedule. NHPs were primed and boosted with mosaic-8b RBD-mi3 in alum and boosted again with mosaic-8b RBD-mi3 in MF59. 8 immunized NHPs and 8 unimmunized NHPs were then challenged with either SARS-2 Delta (4 immunized and 4 unimmunized) or with SARS-1 (4 immunized and 4 unimmunized). Right: Structural model of mosaic-8b RBD-mi3 nanoparticles as shown in Fig. 2A. (B-D) Viruses for assays indicated as different colors; all were mismatched with respect to mosaic-8b RBD-mi3 except for SARS-2 Beta. ELISA and neutralization data for antisera from individual NHPs (open circles) presented as the mean (bars) and standard deviation (horizontal lines). ELISA results are shown as midpoint titers (EC₅₀ values); neutralization results are shown as half-maximal inhibitory dilutions (ID₅₀ values). Dashed horizontal lines correspond to the background values representing the limit of detection.