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[Preprint]. 2022 Mar 30:rs.3.rs-1490282. [Version 1] doi: 10.21203/rs.3.rs-1490282/v1

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Validation and invalidation of dieckol and PGG as SARS-CoV-2 M^pro and PL^pro inhibitors. (A) Flip-GFP M^pro assay results of dieckol and PGG. GC376 was included as a positive control. (B) FRET assay results of PGG against SARS-CoV-2 M^pro, SARS-CoV-2 PL^pro, SARS-CoV PL^pro, and MERS-CoV PL^pro. (C) Thermal shift assay characterization of the binding of PGG to SARS-CoV-2 PL^pro. (D) Flip-GFP PL^pro assay result of PGG. The results are mean ± standard deviation of two repeats.