Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 21;13:834644. doi: 10.3389/fimmu.2022.834644

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Vandebergh, Becelaere, CHARGE Inflammation Working Group, Dubois and Goris

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Forest plot of univariable Mendelian randomization estimates of body mass index, interleukin-6 signaling, interleukin-6 levels and c-reactive protein with risk of multiple sclerosis. Data are displayed as odds ratio (OR) and 95% confidence interval (CI) per SD increase in genetically predicted BMI levels, per unit increase in c-reactive protein (CRP) levels for interleukin-6 (IL-6) signaling UKBB, per unit increase in natural-log transformed CRP levels for IL-6 signaling CHARGE and CRP CHARGE, and per unit increase in natural-log transformed IL-6 levels for IL-6 levels CHARGE. UKBB, UK Biobank; CHARGE, Cohorts for Heart and Aging Research in Genomic Epidemiology; CRP, c-reactive protein; MR, Mendelian randomization; N SNPs, number of variants in the analysis; SNP, single nucleotide polymorphisms; IVW, inverse-variance weighted method.