Table 1.

Univariate and Multivariate Analysis of the Factors Associated with Overall Survival.

Variable	Univariate			Multivariate
	HR	95% CI	P	HR	95% CI	P
Age, years (>60/≤60)	3.53	1.943–6.413	3.5×10–5	3.46	1.882–6.363	<0.0001
Gender (female/male)	0.694	0.276–1.741	0.436			NA
Tumor size (>3 cm/≤3 cm)	1.626	0.896–2.951	0.11			NA
Multifocality (Multifocal/Unifocal)	0.922	0.502–1.695	0.794			NA
Tumor stage (T2–T4/Ta–T1)	3.429	2.009–5.854	6.3×10 –6	2.214	1.163–4.214	0.016
Nodal status (N1–N2/N0)	6.644	2.933–15.051	5.7×10 –6	3.931	1.601–9.65	0.003
Histological grade (High/Low)	2.113	1.236–3.612	0.006	1.003	0.531–1.894	0.992
${\mathrm{CD66b}}_{\text{INT}}^{+}$ Cells (High/Low)	1.954	1.077–3.546	0.028	0.974	0.488–1.944	0.941
${\mathrm{CD66b}}_{\text{ST}}^{+}$ Cells (High/Low)	5.715	2.871–11.374	6.9×10–7	3.477	1.434–8.428	0.006

${\mathrm{CD66b}}_{\text{INT}}^{+}$ Neutrophils, CD66b⁺ Neutrophils in introtumoral regions; ${\mathrm{CD66b}}_{\text{ST}}^{+}$ Neutrophils, CD66b⁺ Neutrophils in stromal regions. UCB, urothelial cell carcinoma of the bladder. HR, hazard ratio; CI, confidence interval; NA, not applicable.

Univariate and multivariate analysis. Cox proportional hazards regression model. Variables associated with survival by univariate analyses were adopted as covariates in multivariate analyses. Significant P-values are shown in bold font. HR > 1, risk for death increased; HR < 1, risk for death reduced.