FIGURE 2.

RRBE induced endothelium-dependent relaxation and suppressed contraction in the porcine’s coronary ring. (A) Intact and endothelium-denuded rings were contracted using U46619 before the addition of increasing concentrations of RRBE (1 μg/ml to 100 μg/ml) to construct concentration-relaxation curves. ***p < 0.001 vs the endothelium. (B) Coronary artery rings were treated with RRBE (10 μg/ml and 100 μg/ml) before constructing the concentration–contraction curve in response to U46619. Results are presented as mean ± SEM of five to seven experiments. ***p < 0.001 vs control. **p < 0.01 vs control.