TABLE 2.

Prediction performance of models for down-regulation pairs using the 5-fold cross validation on the training dataset.

Model	ROC	Sens	Spec	ROCSD	SensSD	SpecSD
GLM	0.787	0.684	0.776	0.028	0.059	0.0302
KNN	0.800	0.646	0.787	0.0149	0.0275	0.0335
SVM	0.799	0.672	0.777	0.0144	0.0349	0.0205
ANN	0.779	0.701	0.719	0.0434	0.0861	0.0365
RF	0.844	0.742	0.803	0.024	0.0411	0.052