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. 2022 Mar 21;9:842532. doi: 10.3389/fcvm.2022.842532

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Copyright © 2022 Piveta, Rodrigues, Vieira, Fischer, Afonso, Daminello, Cruz, Galvão, Filho, Katz and Morhy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in global area strain derived from the three-dimensional speckle tracking echocardiography. Compared to baseline there was a decrease in three-dimensional global area strain (3DGAS) after a lower cumulative dose of doxorubicin (120 mg/m²; p < 0.001). There was a decrease in 3DGAS after 240 mg/m² dose of doxorubicin compared to baseline (p < 0.001).