Table 3.
Echocardiographic parameters in the 5 evaluation stages.
| Variable | Baseline | 120 mg/m2 | 240 mg/m2 | 6 months | 1 year | p-value |
|---|---|---|---|---|---|---|
| Heart rate (beat/min) | 75.8 ± 9.1 | 76.1 ± 10.3 | 75.3 ± 10.5 | 75.1 ± 9.6 | 71.5 ± 10.6 | 0.067 |
| LVEF | 0.64 ± 0.02 | 0.63 ± 0.03 | 0.63 ± 0.03 | 0.63 ± 0.03 | 0.60 ± 0.04 | 0.001 |
| Diastolic dysfunction† | 17 (33.3%) | 22 (44%) | 22 (44%) | 17 (33.3%) | 24 (47%) | 0.169 |
| E-wave (cm/s) | 81.3 ± 18 | 82.2 ± 18.5 | 80.5 ± 19.6 | 83.5 ± 17.6 | 86.5 ± 18.6 | 0.455 |
| A-wave (cm/s) | 74.2 ± 19.9 | 75.8 ± 21.7 | 77.2 ± 20.3 | 76.8 ± 21.8 | 74.2 ± 21.3 | 0.234 |
| DT (ms) | 192 ± 42.2 | 190.5 ± 39.7 | 180 ± 45.1 | 207 ± 59.1 | 208 ± 46.2 | 0.060 |
| E/A ratio | 1.2 ± 0.4 | 1.1 ± 0.4 | 1.1 ± 0.4 | 1.1 ± 0.3 | 1.1 ± 0.4 | 0.120 |
| Septal s′ (cm/s) | 9.2 ± 1.4 | 9.2 ± 1.3 | 9.1 ± 1.3 | 8.8 ± 1.7 | 8.4 ± 1.2 | 0.058 |
| Septal e′ (cm/s) | 10.7 ± 3.0 | 10.2 ± 3.5 | 9.6 ± 2.6 | 9.6 ± 3.7 | 9.0 ± 2.5 | 0.021 |
| Lateral s′ (cm/s) | 10.8 ± 2.9 | 10.3 ± 2.0 | 10 ± 2.1 | 9.2 ± 1.9 | 8.9 ± 1.8 | 0.001 |
| Lateral e′ (cm/s) | 13.5 ± 4.2 | 12.8 ± 4.2 | 12.7 ± 3.6 | 13.1 ± 4.1 | 12.1 ± 4.2 | 0.247 |
| E/e′ ratio | 7.37 ± 1.6 | 7.1 ± 1.9 | 7.1 ± 2.2 | 7.4 ± 1.9 | 7.5 ± 1.8 | 0.617 |
| RV s′ (cm/s) | 13.7 ± 1.9 | 13.6 ± 2.4 | 13.5 ± 2.4 | 12.7 ± 2.1 | 12.5 ± 2.0 | 0.108 |
| TAPSE (mm) | 20.6 ± 4.1 | 19.9 ± 2.3 | 20.2 ± 2.4 | 20.3 ± 2.3 | 20.7 ± 2.9 | 0.635 |
| 2D Speckle Tracking | ||||||
| 2DGLS (%) | −17.8 ± 1.5 | −17.4 ± 1.4 | −17.1 ± 1.4 | −17.0 ± 2.2 | −16.6 ± 2.1 | <0.001 |
| 2DRS (%) | 39.3 ± 9.8 | 36.7 ± 8.6 | 36.3 ± 14 | 35.1 ± 12.1 | 36.5 ± 13.4 | 0.516 |
| 3D Speckle Tracking | ||||||
| 3DGLS (%) | −15.9 ± 2.2 | −15.5 ± 2.2 | −14.8 ± 1.9 | −14.1 ± 6.3 | −14.4 ± 3.2 | 0.043 |
| 3DGRS (%) | 31.7 ± 12.8 | 27.5 ± 10.3 | 26.3 ± 11.6 | 26.2 ± 11.1 | 30 ± 13.1 | 0.043 |
| 3DGCS (%) | −33.8 ± 4.7 | −32.3 ± 5† | −31.2 ± 4.2 | −30.4 ± 6.3 | −30.1 ± 6.5 | 0.023 |
| Twist (°) | 6.1 ± 2.8 | 5.3 ± 3 | 4.8 ± 2.4 | 4.5 ± 2.5 | 5 ± 4.5 | 0.278 |
| Torsion (°/cm) | 2.6 ± 1.4 | 2.5 ± 1.5 | 2.4 ± 1.3 | 1.9 ± 1.1 | 1.9 ± 1.5 | 0.068 |
| Rotation (°) | 5.2 ± 2.9 | 5.1 ± 3.4 | 4.5 ± 2.2 | 4.4 ± 2.1 | 3.8 ± 2 | 0.093 |
| 3DGAS (%) | −45.4 ± 4.1 | −43.2 ± 4.4 | −39.8 ± 3.3 | −39 ± 3.1 | −39 ± 2.9 | <0.001 |
GAS, global area strain; GLS, global longitudinal strain; GCS, global circumferential strain; GRS, global radial LVEF, left ventricular ejection fraction; DT, E-wave deceleration time; RV, right ventricle; TAPSE, tricuspid annular plane systolic excursion; data are expressed as the mean ± SD or as number (percentage). Comparisons made by generalized estimation equations with normal distribution and identity link function.
†
Generalized equations with binomial distribution and logit bond function. p < 0.05 was considered significant.