Table 4.
Standard echocardiographic parameters during the treatment.
| Variable | Baseline | 120 mg/m2 | 240 mg/m2 | p-value* |
|---|---|---|---|---|
| LVEF | 0.64 ± 0.02 | 0.63 ± 0.03 | 0.63 ± 0.03 | 0.178 |
| Diastolic Dysfunction† | 17 (33.3%) | 22 (44%) | 22 (44%) | 0.122 |
| E-wave (cm/s) | 81.3 ± 18 | 82.2 ± 18.5 | 80.5 ± 19.6 | 0.466 |
| A-wave (cm/s) | 74.2 ± 19.9 | 75.8 ± 21.7 | 77.2 ± 20.3 | 0.262 |
| DT (ms) | 192.8 ± 42.2 | 190.5 ± 39.7 | 180 ± 45.1 | 0.269 |
| E/A ratio | 1.2 ± 0.4 | 1.1 ± 0.4 | 1.1 ± 0.4 | 0.054 |
| Septal s′ (cm/s) | 9.2 ± 1.4 | 9.2 ± 1.3 | 9.1 ± 1.3 | 0.663 |
| Septal e′ (cm/s) | 10.7 ± 3.0 | 10.2 ± 3.5 | 9.6 ± 2.6 | 0.019 |
| Lateral s′ (cm/s) | 10.8 ± 2.9 | 10.3 ± 2.0 | 10 ± 2.1 | 0.220 |
| Lateral e′ (cm/s) | 13.5 ± 4.2 | 12.8 ± 4.2 | 12.7 ± 3.6 | 0.156 |
| E/e′ ratio | 7.37 ± 1.6 | 7.1 ± 1.9 | 7.1 ± 2.2 | 0.678 |
| RV s′ (cm/s) | 13.7 ± 1.9 | 13.6 ± 2.4 | 13.5 ± 2.4 | 0.937 |
| TAPSE (mm) | 20.6 ± 4.1 | 19.9 ± 2.3 | 20.2 ± 2.4 | 0.515 |
| Heart Rate (beat/min) | 75.8 ± 9.1 | 76.1 ± 10.3 | 75.3 ± 10.5 | 0.961 |
LVEF, left ventricular ejection fraction; DT, E-wave deceleration time; RV, right ventricle; TAPSE, tricuspid annular plane systolic excursion; data are expressed as the mean ± SD or as number (percentage).
*
After 240 mg/m2 dose of doxorubicin compared to baseline. Comparisons made by generalized estimation equations with normal distribution and identity link function.
†
Generalized equations with binomial distribution and logit bond function. p < 0.05 was considered significant.