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. 2022 Mar 21;9:774550. doi: 10.3389/fmed.2022.774550

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Copyright © 2022 Wertenauer, Brenner Michael, Dressel, Pfeifer, Hauser, Wieland, Mayer, Mutschmann, Roskos, Wertenauer, Moissl, Lorkowski and März.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Predictive values of positive tests (PPV, left) and predictive values of negative tests (NPV, right) of two commercial RDTs for SARS-CoV-2-associated antigens in relation to disease prevalence rates up to 0.05. Black dotted line: hypothetical sensitivity and specificity of 90 and 95% (tier 1); magenta dotted line: hypothetical sensitivity and specificity of 95 and 97.5% (tier 2); green dotted line: hypothetical sensitivity and specificity of 100 and 99% (tier 3). (A) Red solid line: Abbott-RDT; blue solid line: Roche-RDT; (B) stratified according symptomatic and asymptomatic study participants. Red solid line: symptomatic participants, Abbott-RDT; blue solid line: symptomatic participants, Roche-RDT; magenta solid line: asymptomatic participants, Abbott-RDT; light blue solid line: asymptomatic participants, Roche-RDT.