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. 2022 Mar 21;9:774550. doi: 10.3389/fmed.2022.774550

Table 4B.

Number of false-positive and false-negative results in a hypothetical cohort of 10 000 people tested with the Abbott –RDT.

Hypothetical cohort (assumed number = 10,000) Prevalence rate Expected number of true positives Sensitivity (%) Specificity (%) Number of false positives (95% CI)* Number of false negatives (95% CI)*
Symptomatic persons 0.05 500 74.32 99.73 25 (16, 36) 128 (107, 151)
0.10 1,000 74.32 99.73 24 (15, 34) 257 (227, 287)
0.20 2,000 74.32 99.73 21 (13, 31) 513 (472, 556)
Symptomatic persons: SARS-CoV-2 NIM 0.05 500 78.10 99.73 25 (16, 36) 110 (90, 130)
0.10 1,000 78.10 99.73 24 (15, 34) 219 (191, 248)
0.20 2,000 78.10 99.73 21 (13, 31) 438 (398, 479)
Symptomatic persons: SARS-CoV-2
Alpha variant
0.05 500 71.12 99.73 25 (16, 36) 144 (121, 169)
0.10 1,000 71.12 99.73 24 (15, 34) 289 (256, 322)
0.20 2,000 71.12 99.73 21 (13, 31) 577 (532, 622)
Asymptomatic persons 0.005 50 23.28 99.96 4 (1, 9) 38 (27, 51)
0.01 100 23.28 99.96 4 (1, 9) 77 (60, 94)
0.02 200 23.28 99.96 4 (1, 9) 153 (130, 178)
Asymptomatic persons: SARS-CoV-2 NIM 0.005 50 24.39 99.96 4 (1, 9) 38 (27, 50)
0.01 100 24.39 99.96 4 (1, 9) 76 (59, 93)
0.02 200 24.39 99.96 4 (1, 9) 152 (128, 176)
Asymptomatic persons: SARS-CoV-2
Alpha variant
0.005 50 21.58 99.96 4 (1, 9) 39 (28, 52)
0.01 100 21.58 99.96 4 (1, 9) 78 (61, 96)
0.02 200 21.58 99.96 4 (1, 9) 157 (133, 183)
*

mean (2.5%,97.5%).