Table 4B.
Number of false-positive and false-negative results in a hypothetical cohort of 10 000 people tested with the Abbott –RDT.
Hypothetical cohort (assumed number = 10,000) | Prevalence rate | Expected number of true positives | Sensitivity (%) | Specificity (%) | Number of false positives (95% CI)* | Number of false negatives (95% CI)* |
---|---|---|---|---|---|---|
Symptomatic persons | 0.05 | 500 | 74.32 | 99.73 | 25 (16, 36) | 128 (107, 151) |
0.10 | 1,000 | 74.32 | 99.73 | 24 (15, 34) | 257 (227, 287) | |
0.20 | 2,000 | 74.32 | 99.73 | 21 (13, 31) | 513 (472, 556) | |
Symptomatic persons: SARS-CoV-2 NIM | 0.05 | 500 | 78.10 | 99.73 | 25 (16, 36) | 110 (90, 130) |
0.10 | 1,000 | 78.10 | 99.73 | 24 (15, 34) | 219 (191, 248) | |
0.20 | 2,000 | 78.10 | 99.73 | 21 (13, 31) | 438 (398, 479) | |
Symptomatic persons: SARS-CoV-2 Alpha variant |
0.05 | 500 | 71.12 | 99.73 | 25 (16, 36) | 144 (121, 169) |
0.10 | 1,000 | 71.12 | 99.73 | 24 (15, 34) | 289 (256, 322) | |
0.20 | 2,000 | 71.12 | 99.73 | 21 (13, 31) | 577 (532, 622) | |
Asymptomatic persons | 0.005 | 50 | 23.28 | 99.96 | 4 (1, 9) | 38 (27, 51) |
0.01 | 100 | 23.28 | 99.96 | 4 (1, 9) | 77 (60, 94) | |
0.02 | 200 | 23.28 | 99.96 | 4 (1, 9) | 153 (130, 178) | |
Asymptomatic persons: SARS-CoV-2 NIM | 0.005 | 50 | 24.39 | 99.96 | 4 (1, 9) | 38 (27, 50) |
0.01 | 100 | 24.39 | 99.96 | 4 (1, 9) | 76 (59, 93) | |
0.02 | 200 | 24.39 | 99.96 | 4 (1, 9) | 152 (128, 176) | |
Asymptomatic persons: SARS-CoV-2 Alpha variant |
0.005 | 50 | 21.58 | 99.96 | 4 (1, 9) | 39 (28, 52) |
0.01 | 100 | 21.58 | 99.96 | 4 (1, 9) | 78 (61, 96) | |
0.02 | 200 | 21.58 | 99.96 | 4 (1, 9) | 157 (133, 183) |
mean (2.5%,97.5%).