Fractional inhibition of XO, combination index (CI) values and DRI values of techtochrysin and febuxostat in combination dose at different effect levelsa.
| (Fa × 100)% (XO) inhibition of the combined drugs | CI values | Dose (μM) techtochrysin | Dose (μM) febuxostat | DRI techtochrysin | DRI febuxostat |
|---|---|---|---|---|---|
| 53% | 0.39 (Syn) | 0.11 | 0.027 | 4.82 | 5.40 |
| 69% | 0.61 (Syn) | 0.20 | 0.044 | 4.54 | 2.59 |
| 75% | 0.76 (Syn) | 0.25 | 0.054 | 3.06 | 2.27 |
| 84% | 1.26 (Ant) | 0.39 | 0.081 | 1.42 | 1.77 |
| 94% | 1.58 (Ant) | 0.96 | 0.17 | 1.09 | 1.49 |
a
CI < 0.9, (0.9–1.1), and >1.1 indicate synergism (Syn), additive effect (Add), and antagonism (Ant), respectively. Fa signifies fraction affected. DRI > 1 indicates favourable dose reduction (in fold) for the drug in combination.