Fractional inhibition of XO, combination index (CI) values and DRI values of techtochrysin and allopurinol in combination dose at different effect levelsa.
| (Fa × 100)% (XO) inhibition of the combined drugs | CI values | Dose (μM) techtochrysin | Dose (μM) allopurinol | DRI techtochrysin | DRI allopurinol |
|---|---|---|---|---|---|
| 19% | 1.69 (Ant) | 0.031 | 0.29 | 1.32 | 1.06 |
| 35% | 1.48 (Ant) | 0.064 | 0.54 | 1.39 | 1.29 |
| 57% | 1.28 (Ant) | 0.15 | 1.13 | 1.78 | 1.38 |
| 91% | 0.69 (Syn) | 0.98 | 5.76 | 3.51 | 2.36 |
| 97% | 0.53 (Syn) | 3.19 | 15.91 | 3.63 | 3.92 |
a
CI < 0.9, (0.9–1.1), and >1.1 indicate synergism (Syn), additive effect (Add), and antagonism (Ant), respectively. Fa signifies fraction affected. DRI > 1 indicates favourable dose reduction (in fold) for the combination.