TABLE 1.

Mean values of pharmacokinetic parameters for SYN-2836 in mouse plasma after administration of single intravenous doses ranging from 10 to 50 mg/kg

Parameter	10 mg/kg	20 mg/kg	35 mg/kg	50 mg/kg
AUC (μg · h/ml)	11.69 ± 3.07a	25.20 ± 7.9	40.62 ± 6.95	58.3 ± 8.33
CL (ml/min/kg)	15 ± 3.5	14 ± 4	14.5 ± 2.5	14.5 ± 2
Half-life (h)	1.11 ± 0.28b	2.75 ± 0.19	3.14 ± 0.46	2.14 ± 0.15
MRT (h)	0.82 ± 0.33b	2.61 ± 0.78	3.07 ± 0.44	2.18 ± 0.39
VSS (liter/kg)	0.77 ± 0.4b	2.3 ± 1.13	2.71 ± 0.77	1.92 ± 0.55

^aP < 0.05 versus 50 mg/kg. 

^bP < 0.05 versus 20, 35, and 50 mg/kg.