TABLE 2.

Mean values of pharmacokinetic parameters for SYN-2836, SYN-2869, SYN-2903, SYN-2921, and Itraconazole in mouse plasma after administration of a single intravenous dose of 20 mg/kg

Parameters	SYN-2836	SYN-2869	SYN-2903	SYN-2921	Itraconazolea
AUC (μg · h/ml)	25.20 ± 7.9	52.33 ± 5.26b	63.62 ± 26.83b	25.01 ± 1.68	24.73 ± 1.86
CL (ml/min/kg)	14 ± 4c	8.5 ± 3.5	6 ± 3	13.5 ± 1c	9.5 ± 0.5
Half-life (h)	2.75 ± 0.19d	5.56 ± 3.03	4.59 ± 1.68	6.15 ± 1.47	1.59 ± 0.23d
MRT (h)	2.61 ± 0.78	4.17 ± 1.45	4.53 ± 1.67	4.34 ± 0.58	1.47 ± 0.26
VSS (liters/kg)	2.3 ± 1.13	2.73 ± 0.74	2.0 ± 0.28	4.68 ± 0.38e	0.99 ± 0.12

^aIntravenous dose of 15 mg/kg. 

^bP < 0.05 versus SYN-2836 and SYN-2921. 

^cP < 0.05 versus SYN-2869 and SYN-2903. 

^dP < 0.05 versus SYN-2869, SYN-2903, and SYN-2921. 

^eP < 0.05 versus SYN-2836, SYN-2869, and SYN-2903.