TABLE 3.
Mean values of pharmacokinetic parameters for SYN-2836 and SYN-2869 in plasma of New Zealand White rabbits and beagle dogs
| Parameter | New Zealand White rabbits (n = 3)a
|
Beagle dogs (n = 3)b
|
||
|---|---|---|---|---|
| SYN-2836 | SYN-2869 | SYN-2836 | SYN-2869 | |
| Cmax (μg/ml) | 1.26 ± 0.41 | 1.30 ± 0.28 | 4.82 ± 1.54 | 2.19 ± 1.22 |
| Tmax (h) | 1.33 ± 0.28 | 1.66 ± 0.28 | 1.3 ± 0.3 | 2.5 ± 0.8 |
| AUC (μg · h/ml) | 3.74 ± 1.79 | 10.59 ± 2.7 | 41.83 ± 15.79 | 21.85 ± 7.61 |
| CL/F (ml/min/kg) | 277.1 ± 173.5 | 87.7 ± 23.3 | 15.78 ± 5.7 | 28.8 ± 6.6 |
| Half-life (h) | 1.24 ± 0.67 | 5.73 ± 2.7 | 9.0 ± 0.8 | 8.87 ± 2.05 |
| V/F (liters/kg) | 23.48 ± 2.11 | 37.58 ± 9.9 | 9.56 ± 2.31 | 19.74 ± 10.81 |
a
Single oral dose of 50 mg/kg.
b
Single oral dose of 30 mg/kg.