TABLE 4.
Mean values of pharmacokinetic parameters for SYN-2836, SYN-2869, SYN-2903, SYN-2921, and itraconazole in mouse lung after intravenous administration
| Drug (dose [mg/kg]) | AUC (μg · h/ml) | L/P ratioa |
|---|---|---|
| SYN-2836 | 2.73 ± 0.86 | |
| 10 | 38.54 ± 7.4b | |
| 20 | 64.98 ± 8.26b | |
| 35 | 119.44 ± 2.21b | |
| 50 | 190.67 ± 18.21b | |
| SYN-2869 (20) | 128.5 ± 15.5c | 2.32 ± 0.12 |
| SYN-2903 (20) | 100.3 ± 10.78 | 1.79 ± 0.75 |
| SYN-2921 (20) | 66.3 ± 7.31 | 2.65 ± 0.28 |
| Itraconazole | 1.60 ± 0.16 |
a
L/P ratio, ratio of concentration in lungs to concentration in plasma after intravenous administration.
b
Data are significantly different from each other.
c
P < 0.05 versus SYN-2836, SYN-2903, and SYN-2921.