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Mean values of pharmacokinetic parameters for SYN-2836 in plasma of mice, rats, and rabbits after administration of a single intravenous dose of 20 mg/kg
| Parameters | Mice | Rat | Rabbit |
|---|---|---|---|
| AUC (μg · h/ml) | 25.20 ± 7.9 | 12.01 ± 2.08 | 25.6 ± 15.35 |
| CL (ml/min/kg) | 14 ± 4 | 27.4 ± 4.66 | 9.75 ± 1.36 |
| Half-life (h) | 2.75 ± 0.19 | 4.4 ± 4.4 | 1.9 ± 0.8 |
| MRT (h) | 2.61 ± 0.78 | 2.0 ± 0.76 | 3.2 ± 1.8 |
| VSS (liters/kg) | 2.3 ± 1.13 | 4.05 ± 1.75 | 3.38 ± 0.42 |
