Box 1.

Recent developments in single-cell multiomics proteome profiling.

Method	Molecular layers profiled	Proteins profiled	Throughput	References
inCITE-seq	proteins and RNA	intranuclear	+++	Chung et al., 2021
PHAGE-ATAC	proteins and chromatin	surface and intracellular	+++	Fiskin et al., 2021
TEA-seq	proteins, RNA and chromatin	surface	+++	Swanson et al., 2021
DOGMA-seq	proteins, RNA and chromatin	surface and intracellular	+++	Mimitou et al., 2021

Throughput: +++ > 2,000 cells. chromatin = chromatin accessibility.