Table 3.

Major virulence-related proteins described in membrane vesicles of P. salmonis strain type LF-89.

Proteins	Description	Function
Pertussis_S1 superfamily	Pertussis toxin, subunit 1.	Toxin
Enterotoxin A superfamily	Heat-labile enterotoxin alpha chain	Toxin
OM_channels superfamily	Porin superfamily	Porin
OmpA	C-terminal domain of outer-membrane protein OmpA	Bacterial adhesion, invasion, or intracellular survival as well as evasion of host defenses or stimulators of pro-inflammatory cytokine production
Porin F	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA	Porin
VirB9/CagX/TrbG superfamily	VirB9/CagX/TrbG, a component of the type IV secretion system	A component of the type IV secretion system
CsrA superfamily	RNA-binding protein and a global regulator of carbohydrate metabolism genes	This protein is a RNA-binding protein and a global regulator of carbohydrate metabolizm genes facilitating mRNA decay
SrfB superfamily	This family includes homologues of SsrAB is a two-component regulatory system encoded within the Salmonella pathogenicity island SPI-2	This family includes homologues of SsrAB is a two-component regulatory system
FliH superfamily	Flagellar assembly protein FliH.	A component of flagella