Table 4.

Potential Side Effects of Vaccines and Immunotherapeutics

	Therapy Type	Potential Side Effects
Vaccine	BNT162b2, mRNA-1273, AZD1222, Ad26.COV2.S	Fevers, chills,aches, allergic reaction, neurologic complications, fatigue, headache.200
	BNT162b2, mRNA-1273	Injection site pain, fatigue, headache, and myalgia, second dose for both vaccines, particularly for systemic reactions, chills, fever, and joint pain.201,202
	BNT162b2, mRNA-1273	Anaphylaxis.203
	BBIBP-CorV	Fever, injection site pain, tenderness, redness, headache, fatigue, nausea, diarrhea, cough, allergy, muscle pain, abdominal pain,lethargy, back pain.204
	CoronoVac	Pain, redness, swelling, injection site pain, pruritus, cough, fatigue, diarrhea, back pain, hypersensitivity, muscle pain, decreased appetite.205
	BBV152	Headache, fatigue, nausea, vomiting, fever, injection site pain.206
Convalescent Plasma	ClinicalTrials.gov number, NCT04373460	Pneumonitis, headache, hypertension, non-cardiac chest pain, infusion related reaction.86
	ClinicalTrials.gov number, NCT04338360.	Mortality, circulatory overload, acute lung injury, severe allergic transfusion reaction.207
Neutralizing antibodies	Bamlanivimab monotherapy or combination therapy of bamlanivimab and etesevimab	Chills, diarrhea, dizziness, headache, nasal congestion, nausea, pruritus, pyrexia, rash, syncope, vomiting.208
	Casirivimab and imdevimab	Vomiting, nausea, abdominal pain, pruritus, urticaria, chills, flushing.99
T cell/NK cell based therapeutics	NK cells and/or memory T cell infusion	Infusion reactions, side effects related to frozen products, graft-versus-host disease.209