Fig. 11. (A–D) Cerebral cortex sections of albino rats H&E X400. (A)Control rats showing normal structure and distribution of cerebral cortex neurons and neuropil. B: ISO exposed rats revealing neuropil vacuolation (red arrow) and pyknosis of pyramidal cells with pericellular space (yellow arrow). (C)DCM-L200 treated rats showing marked recovery evidenced by diminish of neuropil vacuolation (chevron), pyramidal cells restored its normal shape with vesicular nuclei (red arrow) and few neurons still pyknotic with pericellular space. D: DCM-S200 treated rats revealing marked recovery represented by nearly normal neurons with vesicular nuclei (yellow arrow) but few neurons still pyknotic with pericellular space (chevron) (E–H) Hippocampus sections of albino rats H&E X400. (E)Control rats showing normal structure of; molecular layer (M) that contained neurons (yellow arrow) and glia cell (chevron), pyramidal layer (P) that consisted of triangular shaped cells with central spherical nuclei had prominent nucleoli (red arrow) and polymorphic cell layer (PL) that consisted of neurons (green arrow) and glia cells (chevron). (F)ISO exposed rats revealing chromatolysis of neurons that were surrounded by pericellular spaces (chevron) in molecular (M) and (yellow arrow) in polymorphic layers (PL). The pyramidal cell layer (P) contained shrunken and pyknotic neurons (red arrow), and some pyramidal neurons had karyolitic nuclei (green arrow). Spongiform vacuolation of neuropil (chevron) was observed in polymorphic layer (PL). G: DCM-L200 treated rats showing great restore of the shape of the neurons in M layer (green chevron), in (P) layer (red arrow), and PL (yellow chevron) but few neurons appeared with pericellular space (red chevron). Negligible neuropil vacuolation (black chevron) was observed. H: DCM-S200 treated rats exhibiting marked restore of the shape of the neurons in (P) layer (red arrow) and PL (green chevron) with few neurons with pericellular space (yellow chevron).