TABLE 1.

Description of EMID-AD MBD datasets analyzed per phenotype.

		Baseline		Longitudinal
Category	Phenotype	Sample size	MAF filter	Sample size	MAF filter
Neuropsychological	MMSE	867	0.02	520	0.02
	Attention	806	0.01	402	0.02
	Executive functioning	686	0.01	234	0.02
	Language	849	0.01	409	0.02
	Memory Delayed	729	0.01	337	0.02
	Memory Immediate	797	0.01	345	0.02
	Visuoconstruction	429	0.02	149	0.04
MRI	Fazekas score	606	0.01	n.a.	n.a.
	Cortical thickness	560	0.01	n.a.	n.a.
	Left Hippocampus volume	605	0.01	n.a.	n.a.
	Right Hippocampus volume	605	0.01	n.a.	n.a.
	Summed Hippocampus volume	605	0.01	n.a.	n.a.

“MAF filter” denotes the applied MAF filter for each GWAS. For cross-sectional MMSE we used an MAF threshold of 0.02 due to residual inflation of the GWAS test statistics. Information on tests used for generating baseline and longitudinal phenotypes can be found in Supplementary Material.

MMSE, Mini Mental State Examination. “n.a.”, not available. MRI, Magnetic Resonance Imaging. MAF, Minor Allele Frequency.