TABLE 2.

Genome-wide significant associations observed in GWAS of cognitive phenotypes.

Study arm	Phenotype	Lead variant	Chr	Position	Nearest gene	A1	A2	Beta	MAF	P (SNP)	P (Gene)
Cross-sectional	MemoryDelayed	rs6705798	2p15	63,259,881	EHBP1	C	T	−0.32739	0.358	8.78E-08	1.17E-07
	MMSE	rs2122118	2q33.3	207,252,439	AC017081.2	G	A	−2.82266	0.022	3.03E-09	n.a.
	Visuoconstruction	rs113492235	4q34.2	177,252,900	SPCS3	T	C	−2.17956	0.022	1.51E-08	0.15674
Longitudinal	MemoryImmediate	rs73045836	6q27	169,062,739	SMOC2	G	T	−0.36094	0.020	7.50E-11	0.0035373
	MMSE	rs74381761	8p23.1	9,389,761	TNKS	C	G	−0.08453	0.048	1.89E-08	0.00048716
	Attention	rs116900143	10q23.31	92,588,290	HTR7	C	T	−0.35173	0.023	1.95E-08	0.019663
	MemoryImmediate	rs11217863	11q23.3	120,293,138	AP002348.1	A	G	−0.16626	0.080	7.81E-08	8.91E-07
	Attention	rs111959303	12q14.3	66,844,015	GRIP1	T	C	0.37459	0.022	2.52E-08	0.81478
	Attention	rs34736485	16q23.2	79,272,611	RP11-679B19.2	T	G	0.31924	0.022	1.59E-08	n.a.
	MemoryDelayed	rs9652864	17q24.1	63,741,645	CEP112	A	T	0.29184	0.218	3.20E-08	0.016339
	MemoryImmediate	rs146202660	18q21.1	45,022,937	CTD-2130O13.1	T	G	−0.29342	0.029	4.63E-08	n.a.
	Executive	rs16982556	20q13.32	57,801,889	ZNF831	T	C	−0.29752	0.062	1.26E-08	0.0025565
	Visuoconstruction	rs5943462	Xp21.3	28,823,154	IL1RAPL1	G	C	−0.14082	0.051	1.06E-09	0.006719

Bold font indicates genome-wide significant (on SNP- or gene-level) results (see section Materials and Methods for details). “Chr” and “Position” according to GRCh37/hg19. “A1” denotes the effect allele. “P (SNP)” is the P-value of the lead SNP at this locus. “P (Gene)” is the P-value belonging to “Nearest gene.” Top results from these GWAS analyses can be found in Supplementary Tables 1–19.

MMSE, Mini Mental State Examination. “n.a.”, not available. MRI, Magnetic Resonance Imaging. MAF, Minor Allele Frequency.