TABLE 3.
Summary of PGS results significant after multiple testing correction.
| Prior GWAS | Phenotype | Threshold | Number of SNPs | R 2 | P-value |
| Hibar et al. (2017) | Hippocampus volume sum | 0.0001 | 127 | 0.027 | 6.06E-06 |
| Hippocampus volume left | 0.0001 | 127 | 0.026 | 9.98E-06 | |
| Hippocampus volume right | 0.0001 | 127 | 0.024 | 2.48E-05 | |
| Jansen et al. (2019) | Fazekas | 0.17075 | 22,269 | 0.014 | 3.72E-03 |
| Davies et al. (2018) | Baseline MMSE | 0.248 | 63,792 | 0.016 | 1.66E-06 |
| Baseline executive functioning | 0.0014 | 4,469 | 0.018 | 1.98E-05 | |
| Baseline language | 0.0061 | 9,031 | 0.010 | 1.25E-03 | |
| Longitudinal attention | 5.0E-08 | 163 | 0.023 | 1.79E-03 |
“Threshold” refers to P-value cut-off used for PGS construction in prior GWAS summary statistics and “Number of SNPs” refers to the LD-pruned SNPs passing this threshold that are included in PGS calculations. “R2” denotes the phenotypic variance explained by the SNPs of the prior GWAS in the EMIF-AD MBD dataset. A full listing of results from these PRS analyses can be found in Supplementary Material.
MMSE, Mini Mental State Examination.