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. 2022 Apr 4;17(4):e0266163. doi: 10.1371/journal.pone.0266163

Fig 1. CIRP mRNA expression correlates with α-SMA in IPF patients and is increased during acute exacerbation of IPF.

Fig 1

Examinations of two publicly available gene expression omnibus (GEO) profiles: GSE98925 and GSE10667 (insert): After obtaining mRNA expression data using the getGEO function, expressions were normalized across all samples using the package limma workflow. The figure shows Pearson correlation and the coefficient (R = 0.39) obtained between mRNA expression of CIRP and α-SMA, along with p-value (p = 0.0017) shown for GSE98925, which is the mRNA array profile of microdissection from multiple fibroblastic foci from the lung tissues of 13 IPF patients either from the biopsy or after lung explantation. The insert shows the difference between the normalized CIRP mRNA in stable IPF patients (UIP) vs. those with acute exacerbation of IPF (AEx) in data from GSE10667. Unpaired Student’s t-test was used to determine the significance. * p<0.05 vs. UIP. The sample GSM269765 was removed due to normalized CIRP mRNA for that sample being more than 3 standard deviations away from the means.