Table 3. Baseline cardiovascular characteristics of HCHS/SOL individuals by primary solution derived sleep phenotype.
| Insomnia OSA | Asymptomatic Mild OSA | Symptomatic OSA | Total | P value | ||
|---|---|---|---|---|---|---|
| Unweighted N’s (Weighted %) | 1596 (44.3%) | 1275 (36.2%) | 674 (19.5%) | |||
| HDL Cholesterol (mg/dL)⇞ | 49.1 (14.7) | 47.7 (15.9) | 44.0 (12.4) | 47.6 (14.9) | P<0.001 | Legend |
| Total Cholesterol (mg/dL)⇞ | 206.5 (53.1) | 209.0 (50.0) | 205.8 (55.3) | 207.3 (52.5) | P = 0.489 | Lowest |
| Triglycerides (mg/dL)⇞ | 149.8 (104.6) | 158.8 (130.0) | 175.3 (157.3) | 158.1 (126.5) | P = 0.001 | Medium |
| BMI (kg/m2)⇞ | 31.4 (6.7) | 30.6 (5.9) | 33.7 (7.0) | 31.6 (6.6) | P<0.001 | Highest |
| Cigarette Usage † | ||||||
| Never | 54.1 (2.0) | 55.4 (1.9) | 44.9 (2.6) | 52.8 (1.3) | P = 0.032 | |
| Former | 28.5 (1.6) | 28.7 (1.7) | 33.9 (2.6) | 29.6 (1.1) | ||
| Current | 17.4 (1.6) | 15.9 (1.4) | 21.1 (2.4) | 17.6 (1.0) | ||
| Alcohol Usage † | ||||||
| Doesn’t drink alcohol | 55.4 (1.8) | 53.6 (2.0) | 57.5 (2.4) | 55.2 (1.2) | P = 0.459 | |
| Drinks alcohol | 44.6 (1.8) | 46.4 (2.0) | 42.5 (2.4) | 44.8 (1.2) | ||
| CVD | ||||||
| No CVD | 49.2 (2.0) | 63.2 (1.9) | 47.4 (2.7) | 54.0 (1.3) | P<0.001 | |
| CVD | 50.8 (2.0) | 36.8 (1.9) | 52.6 (2.7) | 46.0 (1.3) | ||
| Heart Failure | ||||||
| No heart failure | 96.4 (0.7) | 97.5 (0.8) | 95.9 (1.0) | 96.7 (0.4) | P = 0.410 | |
| Heart failure | 3.6 (0.7) | 2.5 (0.8) | 4.1 (1.0) | 3.3 (0.4) | ||
| Stroke/TIA † | ||||||
| No Prevalent Stroke/TIA | 94.1 (0.8) | 94.6 (1.1) | 95.8 (0.9) | 94.6 (0.5) | P = 0.541 | |
| Prevalent Stroke/TIA | 5.9 (0.8) | 5.4 (1.1) | 4.2 (0.9) | 5.4 (0.5) | ||
| Hypertension † | ||||||
| Not hypertensive | 43.7 (2.0) | 43.7 (2.1) | 31.8 (2.4) | 41.4 (1.2) | P = 0.001 | |
| Hypertensive | 56.3 (2.0) | 56.3 (2.1) | 68.2 (2.4) | 58.6 (1.2) | ||
| Diabetes † | ||||||
| Non-diabetic | 66.1 (1.9) | 66.6 (2.0) | 57.3 (2.7) | 64.6 (1.3) | P = 0.012 | |
| Diabetic | 33.9 (1.9) | 33.4 (2.0) | 42.7 (2.7) | 35.4 (1.3) | ||
| FRS Score | 0.14 (0.13) | 0.15 (0.13) | 0.20 (0.15) | 0.11 (0.12) | P<0.001 | |
| FRS Score (3 categories) | ||||||
| <0.1 | 37.2 (2.0) | 27.4 (1.7) | 21.0 (1.9) | 30.5 (1.2) | P<0.001 | |
| 0.1-<0.2 | 32.3 (2.0) | 35.5 (2.0) | 34.3 (2.6) | 33.9 (1.1) | ||
| > = 0.2 | 30.4 (1.9) | 37.1 (2.2) | 44.7 (2.8) | 35.6 (1.3) |
Notes:
Unweighted N = 3,545.
* Means and Standard Deviations are presented;
† % and Standard Errors (SEs) are presented
P value: Pearson’s chi square test for continuous variables; Regression based F test for categorical variables
HDL: High-density lipoproteins; BMI: Body Mass Index: Transient Ischemic Attack
The legend indicates which sleep phenotype groups have the highest and lowest values for each variable.