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Schematic of preparation and anti-inflammatory therapy of human serum albumin nanoparticles targeting macrophages. pDNA/DSP-NPs in rheumatoid arthritis (RA) joints through the ELVIS effect, increased demand for rheumatoid joint albumin, the intrinsic high affinity between HSA and locally overexpressed SPARC (secreted protein acidic and rich in cysteine) in synovial tissues of RA, effective treatment of RA.
