Figure 8. Reductions in bAP amplitude have a selective effect on VGCC-mediated calcium influx.

(A) Steady-state open probability of VGCCs and NMDARs as a function of voltage due to voltage-dependent activation of VGCCs and Mg²⁺-block of NMDARs. (B) Voltage-dependent time constant of the activation gate for VGCCs and Mg²⁺ block for NMDARs. (C) We simulated the response of VGCCs and NMDARs to a 1ms (left) or 0.5ms (right) quadratic depolarizing voltage with varying amplitude (1st row) designed to resemble bAPs. Voltage-dependent open-probability (2nd and 3rd rows) and voltage-dependent calcium current (4th and 5th rows) for VGCCs (teal) and NMDARs (black). Purple and red traces correspond to summary data in panels D and E. (D) Peak open probability of VGCCs and NMDARs during quadratic voltage protocols in panel C. (E) Integral of calcium influx through VGCCs and NMDARs during quadratic voltage protocols in panel C.