Table 2.

Inhibitory role of ginseng in inflammasome activation.

Target	Ginseng	Components	Models	Ref.
NLRP3	Panax ginseng	Rb1	3T3-L1, adipose tissue	[55]
			Gouty arthritic rats	[56]
		Rg1	NAFLD mice	[57]
			Liver injury mice	[58,59]
			BNCC337685, diabetic nephropathy rats	[60]
			Diabetic mice	[61]
			Cardiomyocytes, myocardial injury mice	[62]
		Rg2	KC, NAFLD mice	[63]
		Rg3	RAW264.7, sepsis mice	[64]
			BMDMs, THP-1, sepsis mice	[65]
			HK-2, kidney injury mice	[66]
			AC16, HCM, cardiomyocytes, myocardial hypertrophy rats	[67]
		Rg5	Diabetic nephropathy mice	[68]
		Rd	THP-1, colitis mice	[69]
			Cerebral IRI mice	[70]
		Re	Memory impairment mice	[71]
		Rh1	BMDMs, THP-1, sepsis mice	[65]
			KC, NAFLD mice	[63]
		25-OCH3-PPD	HSC-T6, hepatic fibrosis mice	[72]
		CK	Atherosclerotic mice	[73]
			3T3-L1, adipose tissue	[55]
		KRG extract	BMDMs, THP-1, sepsis mice	[65]
		KRG saponins	Aging mice	[74]
	Panax japonicus	CS IVa	BMDMs, adipocytes, obese mice	[75]
			Neurons, POCD rats	[76]
	Panax quinquefolius	PF11	Cognition impaired mice	[77]
	Panax notoginseng	Total saponins	Aging rats	[78]
NLRP1	Panax ginseng	Rg1	Neuronal injury mice	[79]
		Rg1	Hippocampal neurons, neuronal injury mice	[80]
AIM2	Panax ginseng	Rg3	BMDMs, THP-1, sepsis mice	[65]
		Fructose-arginine	BMDMs	[81]
Caspase-11	Panax ginseng	KRG extract	J774A.1, sepsis mice	In press
Caspase-4		Rh2	Human lung cancer cells	[91]