Table 1.
Baseline patient and tumor characteristics of women enrolled in NSABP B-36
| Characteristic | QOL study population |
Other B-36 patients (n=1,391) n (%) | P*†value | |||
|---|---|---|---|---|---|---|
| AC (n=675) n (%) | FEC-100 (n=656) n (%) | P* value | Total (n=1,331) n (%) | |||
| Age (years) | ||||||
| ≤ 49 | 280 (41.5) | 284 (43.3) | 0.50 | 564 (42.4) | 534 (38.4) | 0.03 |
| ≥ 50 | 395 (58.5) | 372 (56.7) | 767 (57.6) | 857 (61.6) | ||
| Race | ||||||
| White | 555 (82.2) | 565 (86.1) | 0.049 | 1120 (84.1) | 1177 (84.6) | 0.84 |
| Black/African American | 75 (11.1) | 52 (7.9) | 127 (9.5) | 130 (9.3) | ||
| Other | 26 (3.9) | 30 (4.6) | 56 (4.2) | 61 (4.4) | ||
| Unknown | 19 (2.8) | 9 (1.4) | 28 (2.1) | 23 (1.7) | ||
| Ethnicity | ||||||
| Hispanic or Latina | 40 (5.9) | 40 (6.1) | 0.91 | 80 (6.0) | 100 (7.2) | 0.34 |
| Not Hispanic or Latina | 590 (87.4) | 576 (87.8) | 1166 (87.6) | 1213 (87.2) | ||
| Unknown | 45 (6.7) | 40 (6.1) | 85 (6.4) | 78 (5.6) | ||
| Hormone receptor status | ||||||
| ER− and PgR− | 227 (33.6) | 227 (34.6) | 0.71 | 454 (34.1) | 488 (35.1) | 0.59 |
| ER+ and/or PgR+ | 448 (66.4) | 429 (65.4) | 877 (65.9) | 903 (64.9) | ||
| Surgery type | ||||||
| Lumpectomy | 457 (67.7) | 453 (69.1) | 0.60 | 910 (68.4) | 933 (67.1) | 0.47 |
| Mastectomy | 218 (32.3) | 203 (30.9) | 421 (31.6) | 458 (32.9) | ||
| Tumor grade | ||||||
| Low | 82 (12.1) | 61 (9.3) | 0.23 | 143 (10.7) | 143 (10.3) | 0.86 |
| Intermediate | 246 (36.4) | 263 (40.1) | 509 (38.2) | 518 (37.2) | ||
| High | 343 (50.8) | 330 (50.3) | 673 (50.6) | 722 (51.9) | ||
| Unknown | 4 (0.6) | 2 (0.3) | 6 (0.5) | 8 (0.6) | ||
|
| ||||||
| Size of primary tumor | ||||||
| ≤ 2 cm | 414 (61.3) | 404 (61.6) | 0.49 | 818 (61.5) | 827 (59.5) | 0.38 |
| 2.1 – 5 cm | 253 (37.5) | 239 (36.4) | 492 (37.0) | 537 (38.6) | ||
| > 5 cm | 8 (1.2) | 13 (2.0) | 21 (1.6) | 25 (1.8) | ||
| Unknown | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (0.1) | ||
| Mean (STD) | Mean (STD) | |||||
| FACT-B TOI | 69.48 (12.15) | 69.73 (11.76) | 0.71 | |||
| SF-36 Vitality subscale | 63.13 (20.11) | 63.20 (19.78) | 0.95 | |||
| Symptoms score | 13.84 (10.97) | 14.11 (11.60) | 0.66 | |||
| SF-36 PF-10 subscale | 76.43 (23.08) | 78.53 (21.51) | 0.09 | |||
*
P value is based on the chi-square test for categorical variables, t-test for continuous measures.
†
To compare patients who participated in the QOL sub-study to other B-36 patients.